Biofabrications with much promising
Bioprinter
The spending on health cares of the the
US amounted to 25,095 hundred million US dollars in 2009, accounting for
17.6% of US GDP, 40% of national income and is expected to reach 43,532 hundred
million dollars to 2018, acounted for 20.3% GDP. (United States Department of
Health and Human Services, http://www.hhs.gov/)
Among these demands, the Biofabrication has consistant increasing contribution
in the huge biomedical research and clinical applications.
Biofabrication is persistently and rapidly developing with the improvement of
biomaterials--bioinks and advanced bioprinter technologies, allowing us to build
biofabrication systems including for,
1. Bone tissue repair and regeneration
|
2. Complexed scaffolds for soft tissues |
3. Cell proliferation, migration, and tissue formation
|
4. Drug testing, discovery and screening
|
5. Medical aid, wond healing
|
6. Diseased tissue and oganisim models, etc. |
To achieve a realistic time frame for building organized clinically-relevant
sizes biofabrication constructs, we Regenovo_ABDC) have extensive emphasis on the Robotic
Dispensing Bioprinter, among others types of bioprinters(as that of the
stereolithography (light-curing), electrospinning, laser induced forward
transfer, inkjet modules that we could include as addition modules),
is the most promising bio-printer both for spatial resolution, print speed,
material and cost considerations.
Table 1. Typical characteristics of three key dispensing approaches in
biofabrication
|
Laser-induced
forward transfer |
Inkjet printing |
Robotic
dispensing |
Resolution |
++ |
+ |
+/- |
Fabrication
speed |
- |
+/- |
++ |
Hydrogel
viscosity |
+/- |
- |
+ |
Gelation speed |
++ |
++ |
+/- |
Reference: Advanced Materials, 25th Anniversary Article:
Engineering Hydrogels for Biofabrication--3 Hydrogel Based Biofabrication
Systems
http://onlinelibrary.wiley.com/wol1/doi/10.1002/adma.201302042/full
Base on these key considerations and demands for
our bioprinters , we have continous efforts to improve resolution,
stability, flexibility and most affordable cost for researchers and clinical
developers.
Features of our Bioprinter
1. Viable
cells/biomaterial 3D printing, most cell survival ratio, much cell
than 90%, for longest survival of 4 months,
, with global technology leading levels for the living cells printing.
Based on
Robotic
dispensing,
printable materials are "Unrestricted", as solution, slurry, gel or melt,
etc., with high freedom of choices.
2. The solid state cooling and heating temperature control system
Using an independent solid state cooling elements, and by the liquid heat
transfer medium and micro-flow channel network, to realize the thermal
conductivity and temperature control for the print stage and nozzle. The system
is highly integrated with precise temperature control, easy extention and
operation.
3. Specially
designed unique multi-nozzles technology
Multi-nozzles can be manually or automatically loaded/exchanged for
interleaved 3D, multi-material heterogenously located, and multi-layer, multi
process steps constructions.
High-temperature nozzle temperature range 50-260
℃, low
temperature nozzle range for -5-65℃, can be used
to print biological materials that could be melt in between -5
℃
to 260 ℃ or in
semi-fluid state.
The High-temperature nozzle is manufactured by integrally molded 3D printing
technology(SLS), with the optimal design of the heat exchange efficiency,
and supports the molten state biological material printing from 50
℃ to 260
℃.
The Low
temperature nozzle can cover -5
℃(-20
℃
option) to 65 ℃
precise temperature control, specially oriented low temperature print way to
ensure the vitally
active state of soft tissue biomaterials.
The pneumatic
extrusion
nozzle type may have least or have no material leakage while the extrusion is
paused or the position is shifted.
The screw extruder nozzle type
can produce high extrusion propulsion power, that is suitable for extrusion of
high pressure tolerance and viscosity materials.
4. The precise temperature control:
Localized
temperature control with accuracy of +/- 0.1
℃,
ensuring a constant temperature and cell activity and can realize best spatial
repeatability and process reproducibility of the bio-fabrication.
5. Precise controllable internal porosity and ways to print with multiple angles, ensuring
that the internal holes of the porous
structure are 100% connected, providing similarity as in vivo cell growth
microenvironment.
6. Clean Design
The overall structure and materials of the 3D printing system are sterile design
to ensure a clean working environment and processes, and are suitable for 3D
printing of biological materials and cells under sterile conditions.
Integrated supported professional sterile equipment, ensuring chance of
contamination is less than 10%.
7. Print Stage space
Large molding
range, 160 x 160 x 150mm.
with custom range available.
8. Display, editing and controls of a three-dimensional models
Implement features such as view, rotate, scale, move and mirror of 3D model, 3D
model slicing, and motion stage and 3D model printing controls, etc.
Free design with CAD softwares, have external shape and internal structure
according to the model
implementation requirements.
9. Integrated development teams
Integrated developed by Regenovo Biotechnology Co.Ltd. and Hangzhou University
of Electronic Science and Technology, with completely independent intellectual
property rights, and can implement partial customization according to specific
user requirements to realize adjustable and diverse needs.
10. Solid Living Cell Print foundation: Professor Xu Mingen, our chief
scientist and colleagues have dedicated in Cell-Printing for more than 8 years,
and have prominent contributions in the bio-3D Print field.
Generic Specifications
Air pressure: 0.6-0.8Mpa
Support plate: -5 ~ 65
℃/-20~65℃
Size & Weight: 64x50x70cm/50kg or 85x61x65cm/150kg
Data format: direct support for STL, GCODE, and customized proprietary format.
Operating System: Windows System
Power supply: 100-240V AC, 20A, 50/60Hz
Nozzle cleaning: with self-cleaning function
Customizable options
a.Lab & manufacturing process optimization.
b.Additional
modules, as :
Stereolithography (Light-Curing), Electrospinning, Laser
induced forward transfer modules,etc.
Cooperative partners
Based on progressive and open main frame, we have
vigorous and intensive cooperations with our partners and power users in many
advanced institutions, for instrument optimization, integrated process
optimization, bio-material conditioning and tuning, to advanced bio-print and
bio-fabrication projects and goals.
Part of our consitantly increasing partners:
Affiliated Hospital of People's Liberation Army General
Hospital (304)
Brain Hospital of Tianjin, China Armed Police (Armed
Forces Institute of traumatic brain injury and neurological disease)
Affiliated Drum Tower Hospital of Nanjing University
West China Hospital, Sichuan University, Research Center
for Regenerative Medicine
117 Hospital of People's Liberation Army
Guangzhou Medical College
Stomatology Hospital of Zhejiang University (Biomedical
Engineering and Instrument Science)
Hangzhou University of Electronic Science and Technology
(Institute of Bio-medical engineering and instrumentation)
South China University of Technology (country rebuild
human tissue engineering technology research center)
Shanghai Jiaotong University
(State Key Laboratory of Metal Matrix Composites) ), etc...
We (Regenovo_ABDC) are a global technology and markiting partners, and cooperate
seamlessly with research institutions, industry, universities, users for
practical demands and successfully developed 3D-BioPrinting systems with
independent intellectual properties and provide our users with flexible
advantages, as expansion, modification, and innovative R&D applications.
Welcome to correspond for discussing your current demand and future
developments.
http://www.chromnet.net/
The Regenovo is a high-tech enterprises specialized to provide integrated 3D
Bio-Printing technology solutions in the biomedical field, and committed to the
development of Bio-Printers
bio-materials and software in the biomedical fields, with core research and
development technologies.
http://regenovo.com/
(Click
image for large images)
|
We (ABDC) have more than 20 years continuous efforts in the research and
production of lab instrument,
software and hardware, and have experiences on the 3D bio and food printing
technology.
http://www.chromnet.net/
The Shining 3D Technology(Shining), is the largest 3D scanning and
printing-related product development and distribution company, and also is one
of the major technical partner of Regenovo.
http://www.shining3d.cn/zh-cn/
Media/Video
CCTV_InterviewVideos.avi
3D BioPrinting--Human Organs Introduction Videos 0001.flv
(Download Free FLV Player :
http://applian.com/flvplayer/)
3D BioPrinting--Human Organs Introduction Videos 0002.flv
3D BioPrinting--Human Organs Introduction Videos 0003.flv
3D BioPrinting--Human Organs Introduction Videos 0004.flv
CCTV4 report .zip (mpg) report .zip (mpg)
Regenovo
biomaterials_SLA.avi
Regenovo Cell
print.avi
Reuters-Chinese bio-printer to ease national organ short.flv
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